Love laughs at Locksmiths: Ubiquitylation of p62 unlocks its autophagy receptor potential
نویسندگان
چکیده
منابع مشابه
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-kappaB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These findings place p62 at critical decision points that control cell death and survival.
متن کاملAutophagy Suppresses Tumorigenesis through Elimination of p62
Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism. While tumor cells utilize autophagy to survive metabolic stress, autophagy also mitigates the resulting cellular damage that may limit tumorigenesis. In response to stress, autophagy-defective tumor cells preferentially accumulated...
متن کاملAutophagy and p62 in cardiac proteinopathy.
RATIONALE Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB(R120G)) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy. Mechanisms underlying the response of cardiomyocytes to proteotoxic stress remain incompletely understood. OBJECTIVE Our first objective was to determine...
متن کاملTRIB3-P62 interaction, diabetes and autophagy
Type 2 diabetes (T2D) and cancer are two common diseases with tremendous impact on health worldwide. Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetic risk factors and diabetic medications. Generally, hyperinsulinemia and high level of circulating Insulin-like growth factor 1 (IGF-1) contribute to cancer development through the insulin...
متن کاملFeedback on Fat: p62-mTORC1-Autophagy Connections
Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Research
سال: 2017
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2017.56